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Immunoglobulin Products - Quick Guide


Products

NZBS provides human immunoglobulin concentrate of IgG antibodies prepared from pooled plasma donations in three formulations:

  • for subcutaneous use
  • for intravenous use
  • for intramuscular use

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Australian NBA IVIG Guideline


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English NHS IVIG Guideline

Subcutaneous products

  • There are currently two subcutaneous products available in New Zealand. Please check administration instructions before use.
  • HizentraNZ
    a 20% solution, is prepared from New Zealand donors' plasma by CSL Behring. This is the new default subcut immunoglobulin product.
  • Hizentra
    As New Zealand is not entirely self-sufficient for subcutaneous immunglobulin, we also have Hizentra, manufactured in exactly the same way as HizentraNZ but from European and American donor plasma.

Intravenous products

  • There are several different intravenous products available in New Zealand. The different products have different rates for administration. Please check before use.
  • PrivigenNZ
    a 10% solution prepared from New Zealand donor plasma and manufactured by the same company that made IntragamP, CSL Behring. ProvigenNZ is being rolled out nationally and replaces IntragamP.
  • Privigen
    a 10% solution manufactured in exactly the same way and the same plant as as PrivigenNZ but from European and American donor plasma. New Zealand is approximately 90% self-sufficient as a country for IVIG. For the remainder, we have Privigen.
  • Gamunex
    a 10% IVIG solution manufactured by Grifols. This is only for patients who cannot tolerate Privigen or PrivigenNZ. We have a small stock of Gamunex. This is available only after discussion with a New Zealand Transfusion Medicine Specialist.

Intramuscular product

There are currently two non-specific intramuscular products in New Zealand. These are usually for hepatitis A and measles prophylaxis but may occasionally used as a replacement immunoglobulin for hypogammaglobulinaemia.

Hyperimmune products

Hyperimmune immunoglobulins are also pooled immunoglobulin concentrates but with a known level of activity against a named virus or protein. Hyperimmune immunoglobulins prepared from New Zealand donors' plasma are Anti-D, Hepatitis B Immunoglobulin, Tetanus Immunoglobulin and Zoster Immunoglobulin. Other hyperimmune immunoglobulins are available as Section 29 products.

Datasheets

More Info